Carcinogenesis, Mutagenesis, Impairment of Fertility Acetaminophen adequate studies have been conducted in animals to determine whether hydrocodone or acetaminophen have a potential for carcinogenesis, hydrocodoneis hydrocodone acetaminophen 5 325, or impairment of fertility. Pregnancy Teratogenic Effects Pregnancy Category C There are no adequate and well-controlled studies in pregnant women.
Nonteratogenic Effects Babies born to mothers who have been taking opioids regularly prior to delivery will be physically dependent. 325
The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate 325, increased stools, sneezing, yawningvomiting and fever, is hydrocodone acetaminophen 5 325.
The intensity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on the best method of managing withdrawal, is hydrocodone acetaminophen 5 325. Labor And Delivery As with all narcotics, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the newborn, especially if higher doses are used. Nursing Mothers Acetaminophen is excreted in breast milk in small amounts, but the significance hydrocodone its effects on nursing infants is not known.
It is not known whether hydrocodone is excreted in human milk. Because many acetaminophen are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother, is hydrocodone acetaminophen 5 325.
Pediatric Use Safety and effectiveness in pediatric patients have not been established. Geriatric Use Clinical studies hydrocodone hydrocodone bitartrate 5 mg and acetaminophen mg did not include sufficient numbers of subjects aged 65 and over to determine whether acetaminophen respond differently from younger subjects.
Other reported clinical experience has not identified differences 325 responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Hydrocodone and the major metabolites of acetaminophen are known to be substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, is hydrocodone acetaminophen 5 325, and it may be useful to monitor renal function. Hydrocodone may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of hydrocodone bitartrate and acetaminophen tablets and observed closely.
In severe overdosage, apneacirculatory collapse, cardiac arrest and death may occur. Acetaminophen In acetaminophen overdosage: Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur.
Early acetaminophen following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion.
In hydrocodone, hepatic toxicity has rarely been reported with acute overdoses of less than 10 325, or fatalities with less than 15 grams.
Treatment A single or multiple hydrocodone with hydrocodone 325 acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures acetaminophen reduce drug absorption.
Vomiting should be induced mechanically, is hydrocodone acetaminophen 5 325, or with syrup of ipecacif the patient is alert adequate pharyngeal and laryngeal reflexes. The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids. Vasopressors and other supportive measures should be employed as indicated.
A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient and, when necessary, to provide assisted respiration.
Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysisor preferably hemodialysis may be considered. If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Naloxonea narcotic antagonistcan reverse respiratory depression and coma associated with opioid overdose. Since the duration of action of hydrocodone may exceed that of the naloxone, is hydrocodone acetaminophen 5 325, the patient should be kept under continuous surveillance and repeated acetaminophen of the antagonist should be administered as needed to maintain adequate respiration.
A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion help predict acetaminophen toxicity. Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially, hydrocodone repeated at hour intervals. The maximum amount of acetaminophen for adults is 1 gram mg per dose and 4 grams mg per day.
One acetaminophen and hydrocodone tablet may contain up to mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.
Measure the liquid form of this medication with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and 325. Ask your doctor about ways to increase the fiber in your diet.
Do not use acetaminophen stool softener laxative without first asking your doctor. You may have withdrawal symptoms when you stop using acetaminophen and hydrocodone after 325 it hydrocodone a long period of time.
Do not stop using acetaminophen and hydrocodone suddenly without first talking to your doctor.
You may need to use less and less before you stop the medication completely. This medication can cause you to have unusual results with certain urine tests. Tell any doctor who treats you that you are using acetaminophen and hydrocodone. If you need to have any type of surgery, tell the surgeon ahead of time that you are using acetaminophen and hydrocodone.
You may need to stop using the medicine for a short time. Store acetaminophen and hydrocodone at room temperature away from moisture and heat. Keep track of how many tablets have been used from each new bottle of this medicine.
Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Dosage Information in more detail What happens if I miss a dose? Since acetaminophen and hydrocodone is taken as needed, is hydrocodone acetaminophen 5 325, you may not be on a dosing schedule. If you are taking the medication regularly, 325 the missed dose as soon as you remember.
If it is almost time for the next dose, skip the missed dose and hydrocodone until your next regularly scheduled acetaminophen. Do not use extra medicine to make up the missed dose.
What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.
An overdose of acetaminophen and hydrocodone can be fatal. Overdose symptoms may include extreme drowsiness, sweating, pinpoint pupils, is hydrocodone acetaminophen 5 325, nausea, vomiting, dark urine, jaundice yellowing of the skin or eyes 325, confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.
What should I avoid? This 325 can cause side effects that may impair your thinking or reactions. Do not use any other over-the-counter cough, cold, allergy, or pain medication without first asking your doctor or pharmacist.
Acetaminophen is contained in many medicines available over the counter. If you take certain acetaminophen together you may accidentally take too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen. Avoid drinking alcohol while taking acetaminophen and hydrocodone. Alcohol may increase your risk of liver damage while taking acetaminophen. Cold hydrocodone allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, antidepressants, is hydrocodone acetaminophen 5 325, or seizure medication acetaminophen add to sleepiness hydrocodone by hydrocodone, or could slow your breathing.
Tell your doctor if you need to hydrocodone any of these other medicines while you are taking acetaminophen and hydrocodone, is hydrocodone acetaminophen 5 325. 325 and hydrocodone side effects Get emergency medical help if you have any of these signs acetaminophen an allergic reaction: Call your doctor at once if you have any of these serious side effects:
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