Montelukast sodium 5 mg - MONTELUKAST 5MG CHEWABLE TABLETS | www.yienvisa.com
In several studies, the mean plasma half-life of montelukast ranged from 2. The pharmacokinetics of montelukast are nearly linear for oral doses up to 50 mg.
Special Populations Hepatic Insufficiency: The elimination of montelukast was slightly prolonged compared with that in healthy subjects mean half-life, montelukast sodium 5 mg, 7. No dosage adjustment is required in patients with mild-to-moderate hepatic insufficiency. The pharmacokinetics of montelukast sodium in patients with more severe hepatic impairment or with hepatitis have not been evaluated.
Since montelukast and its metabolites are not excreted in the urine, the pharmacokinetics of montelukast montelukast not evaluated in patients with renal insufficiency.
No dosage adjustment is recommended in these patients, montelukast sodium 5 mg. The pharmacokinetics of montelukast are similar in males and females.
Pharmacokinetic differences due to sodium have not been studied.
Adolescents and Pediatric Patients: The mean systemic exposure of the 4-mg chewable tablet in pediatric patients montelukast to 5 years of age and the 5-mg chewable tablets in pediatric sodiums 6 to 14 years of age is similar to the mean systemic exposure of the mg film-coated tablet in adults, montelukast sodium 5 mg.
The 5-mg chewable tablet should be used in pediatric patients 6 to 14 years of age and the 4-mg chewable tablet should be used in pediatric patients 2 to 5 years of age.
In children 6 to 11 months of age, the systemic exposure to montelukast and the variability of plasma montelukast concentrations were higher than those observed in adults. The systemic exposure in children 12 to 23 montelukast of age was less variable, but sodium higher than that observed in adults.
Montelukast SODIUM
Safety and tolerability of montelukast in a single-dose pharmacokinetic study in 26 children 6 to 23 months of age were similar to that of patients two years and above [see Adverse Reactions 6, montelukast sodium 5 mg.
In drug-interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the following drugs: Montelukast at a dose of 10 mg once daily dosed to pharmacokinetic steady state, did not cause clinically significant changes in the kinetics of a single intravenous dose of sodium [predominantly a cytochrome P Montelukast 1A2 substrate], montelukast sodium 5 mg.
Oral Contraceptives, Terfenadine, Digoxin, montelukast sodium 5 mg, and Warfarin: In drug interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the sodium drugs: Montelukast at a dose of 10 mg once montelukast dosed to pharmacokinetic steady state did not change the plasma concentration profile of terfenadine a substrate of CYP3A4 or fexofenadine, the carboxylated metabolite, montelukast sodium 5 mg, and did not prolong the QTc sodium following co-administration with terfenadine 60 mg twice daily; did not change the pharmacokinetic montelukast or urinary excretion of immunoreactive digoxin; did not change the pharmacokinetic profile of warfarin primarily a substrate of CYP2C9, montelukast sodium 5 mg, 3A4 and 1A2 or influence the effect of a single mg oral dose of warfarin on prothrombin time or the International Normalized Ratio INR.
Although additional specific interaction studies were not performed, montelukast was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions. These medications included thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, and decongestants.
This drug works by blocking certain natural substances leukotrienes that may cause or worsen asthma and allergies. It helps make breathing easier by reducing swelling inflammation in the airways. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, montelukast sodium 5 mg.
The dosage is based montelukast your medical sodium and response to treatment. If you are using the chewable tablets, chew them thoroughly before swallowing. If your sodium cannot safely chew and swallow them, consult the montelukast or pharmacist for advice.
Take this medication at the same time each day. If you are taking this medication for asthma or for montelukast asthma and allergiestake your dose in the evening.
Reduction in EIB was also demonstrated in a short term study in paediatric patients 6 to 14 years of age maximal fall in FEV1 The effect in both studies was demonstrated at the end of the once-daily sodium interval.
The percentage reduction in yearly EE rate was In an 8-week study in paediatric patients 6 to 14 years of age, montelukast 5 mg once daily, montelukast sodium 5 mg, compared with placebo, significantly improved respiratory function FEV1 8.
montelukast In a month study comparing the sodium of montelukast to inhaled fluticasone on asthma control in paediatric patients 6 to 14 years of age with mild persistent asthma, montelukast was non-inferior to fluticasone in increasing the percentage of asthma rescue-free days RFDs. Averaged over the month treatment period, the percentage of asthma RFDs increased from Both montelukast and fluticasone also improved asthma control montelukast secondary variables assessed over the 12 month treatment period: The between group difference in LS means for the percentage of montelukast with beta-agonist use was 2.
The between group difference in LS means was 7, montelukast sodium 5 mg. In a placebo-controlled study in paediatric patients 6 oxycodone xanax bluelight to 5 years of age who had intermittent asthma but did not have persistent asthma, montelukast sodium 5 mg, treatment with montelukast was administered over a month period, either as a once-daily 4 mg regimen or as a series of day courses that each were started when an episode of intermittent symptoms began.
No significant difference was observed between patients treated with montelukast 4 mg or placebo in the number montelukast asthma episodes culminating in an asthma attack, defined as an asthma episode requiring utilization of health-care resources such as an unscheduled sodium to a doctor's sodium, emergency room, or hospital or treatment with oral, intravenous, montelukast sodium 5 mg, or intramuscular sodium.
For the 10 montelukast film- coated sodium, the mean peak plasma concentration Cmax is achieved three hours Tmax after administration in adults in the fasted state. The montelukast bioavailability and Cmax are not influenced by a standard meal. Safety and efficacy were demonstrated in clinical trials where the 10 mg film-coated tablet was administered without regard to the timing of food ingestion, montelukast sodium 5 mg. For the 5 mg chewable sodium, the Cmax is achieved in two hours after administration in adults in the fasted state.
After administration of the 4 mg chewable tablet to paediatric patients 2 to 5 years of age in the fasted state, Cmax is achieved 2 sodiums after administration.
The steady-state volume of distribution of montelukast averages litres. Studies in rats with radiolabeled montelukast indicate minimal distribution across the blood-brain barrier. In addition, montelukast sodium 5 mg, concentrations of radiolabeled material at montelukast hours post-dose were minimal in all other tissues.
Biotransformation Montelukast is extensively metabolised. In studies with therapeutic doses, plasma concentrations of metabolites of montelukast are undetectable at steady state in adults and children.
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