Selegiline 2 mg - Selegiline - FDA prescribing information, side effects and uses
View All Selegiline Description Selegiline selegiline is a levorotatory acetylenic derivative of phenethylamine.
It is commonly referred to in the clinical and pharmacological literature as l- deprenyl, selegiline 2 mg. The chemical name is: It is a white to near white crystalline powder, selegiline 2 mg, freely soluble in water, chloroform, and methanol, and has a molecular weight of The molecular formula is C13H17N.
HCI and the structural formula is as follows: Each capsule, for oral administration contains 5 mg of Selegiline hydrochloride, selegiline 2 mg. In addition, each capsule contains the following inactive ingredients: Inhibition of monoamine oxidase, type B, activity is generally considered to be of primary importance; in addition, there is evidence selegiline Selegiline may act through other mechanisms to increase dopaminergic activity.
Selegiline is best known as an irreversible inhibitor of monoamine oxidase MAO selegiline, an intracellular enzyme selegiline with the outer membrane of mitochondria, selegiline 2 mg. Because Selegiline has greater affinity for type B rather than for type A active sites, it can serve as a selective inhibitor of MAO type B if it is administered at the recommended dose.
MAOs are widely distributed throughout the body; their concentration is especially high in liver, kidney, stomach, intestinal wall, and brain.
5 3 Levodopa:carbidopa, entacapone, tolcapone, selegiline, ropinirole, pramipexole, amantadine
MAOs are currently subclassified into two types, selegiline 2 mg, A and B, which differ in their substrate specificity and tissue distribution.
In CNS neurons, MAO plays an important role in the catabolism of catecholamines dopamine, norepinephrine and epinephrine and serotonin. MAOs are also important in the catabolism of various exogenous amines found in a variety of foods and drugs.
MAO in the GI tract and liver primarily type Selegilinefor example, is thought to provide vital protection from exogenous amines e, selegiline 2 mg. Subsequent release of the displaced norepinephrine causes the rise in systemic blood pressure, etc.
Although rare, a few reports of hypertensive reactions have occurred in patients receiving Selegiline at the recommended dose, with tyramine-containing foods. In addition, one case of hypertensive crisis has been reported in a patient taking the recommended dose of Selegiline and a sympathomimetic medication, ephedrine.
The pathophysiology of the 'cheese reaction' is complicated and, in addition to its ability to inhibit MAO B selectively, Selegiline's relative freedom from this reaction has been attributed to an ability to prevent tyramine and other indirect acting sympathomimetics from displacing norepinephrine from adrenergic neurons. It is important to be aware that Selegiline may have pharmacological effects unrelated to MAO B inhibition.
Selegiline Hydrochloride 10 mg/mL in Pluronic Lecithin Organogel
As noted above, there is some evidence that it may increase dopaminergic activity by other mechanisms, including interfering with dopamine re-uptake at the synapse, selegiline 2 mg. Effects resulting from Selegiline administration may also be mediated through its metabolites, selegiline 2 mg. Two of its three principal metabolites, amphetamine and methamphetamine, have pharmacological actions of their own; they interfere with neuronal uptake and enhance release selegiline several neurotransmitters e.
However, the extent to which these metabolites contribute to the effects of Selegiline are unknown. Rationale selegiline the use of a Selective Monoamine Oxidase Type B Inhibitor in Parkinson's Disease Many of the prominent symptoms of Parkinson's disease are due to a deficiency of striatal dopamine that is the consequence of a progressive degeneration and loss of a population of dopaminergic neurons which originate in the substantia nigra of the midbrain and project to the basal ganglia or striatum.
Early in the course of Parkinson's Disease, the deficit in the selegiline of these neurons to synthesize dopamine can be overcome by administration of exogenous levodopa, usually given in combination with a peripheral decarboxylase inhibitor carbidopa, selegiline 2 mg. Thus, after several years of levodopa treatment, the response, for selegiline given dose of levodopa, is shorter, has less predictable onset and offset i.
Selegiline Hcl
A newer anti-Parkinson MAO-B inhibitor, selegiline 2 mg, rasagilinemetabolizes into 1 R -aminoindan, which has no amphetamine-like characteristics. Transdermal dosing results in significantly higher exposure selegiline selegiline and lower exposure to all metabolites when compared to oral dosing; this doxycycline treating strep throat due to the extensive first-pass metabolism of the pill form and low first-pass metabolism of the patch form.
The site of application is not a significant factor in how the drug is distributed. In humans, selegiline does not accumulate in the skin, selegiline 2 mg, nor is it metabolized there. Selegiline is an L -methamphetamine derivative with a propargyl group attached to the nitrogen atom. This detail is borrowed from pargylinean older phenethylamine MAO-B inhibitor.
Phenothiazine derivatives and central nervous system stimulants should be avoided. Hypotension and vascular collapse should be treated with intravenous fluids and, if necessary, blood pressure titration with an intravenous infusion of a dilute pressor agent. It should be noted that adrenergic agents may produce a markedly increased pressor response, selegiline 2 mg. Respiration should be supported by appropriate measures, including management of the airway, use of supplemental oxygenand mechanical ventilatory assistance, as required.
Body temperature should be selegiline closely. Intensive management of hyperpyrexia may be required. Maintenance of selegiline and electrolyte balance is essential.
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This contraindication is often extended to other opioids. Inhibition of monoamine oxidase, type B, activity is selegiline considered to be of primary importance; in addition, selegiline 2 mg, there selegiline evidence that selegiline may act through other mechanisms to increase dopaminergic activity. Selegiline is best known as an irreversible inhibitor of monoamine oxidase MAOan intracellular enzyme associated with the outer membrane of mitochondria.
Because selegiline has greater affinity for type B rather than for type A active sites, it buying augmentin uk serve as a selective inhibitor of MAO type B if it is administered at the recommended dose, selegiline 2 mg.
MAOs are widely distributed throughout the body; their concentration is especially high in liverkidneystomachintestinal wall, and brain. MAOs are currently subclassified into two types, A and B, which differ in their substrate specificity and tissue distribution.
In CNS neurons, MAO plays an important role in the catabolism of catecholamines dopaminenorepinephrine and epinephrine and serotonin. MAOs are also important in the catabolism of various exogenous amines found in a variety of foods and drugs. MAO in the GI tract and liver primarily type Aselegiline 2 mg, for example, is thought to provide vital protection from exogenous amines e.
Selegiline
Subsequent release of the displaced norepinephrine causes the rise in systemic blood pressureetc. In theory, since MAO A of the gut is not inhibited, patients treated with selegiline selegiline a dose of 10 mg a day should be able to take medications containing pharmacologically active amines and consume tyramine-containing foods without risk of uncontrolled hypertension.
Although rare, a few reports of hypertensive reactions have occurred in patients receiving Eldepryl selegiline hcl at the recommended dose, with tyramine-containing foods. In addition, one case of hypertensive crisis has been reported in a patient taking the recommended dose of selegiline and a sympathomimetic medication, ephedrine.
The pathophysiology of the 'cheese reaction' is complicated and, selegiline 2 mg, in addition to its ability to inhibit MAO B selectively, selegiline's relative freedom from this reaction has been attributed to an ability to prevent tyramine and other indirect acting sympathomimetics from displacing norepinephrine from adrenergic neurons. However, selegiline 2 mg, until the selegiline of the cheese reaction is more completely understood, selegiline 2 mg, it seems prudent to assume that selegiline can ordinarily only be used safely without dietary restrictions at doses where it presumably selectively inhibits MAO B e.
Selegiline short, attention to the dose dependent nature of selegiline's selectivity is critical if it is to be used without elaborate restrictions being placed on diet and concomitant drug use although, as noted above, a few cases of hypertensive reactions have been reported at the recommended dose. It is important to be aware that selegiline may have pharmacological effects unrelated to MAO B inhibition.
As noted above, there is some evidence that it may increase dopaminergic activity by other mechanisms, including interfering with dopamine re-uptake at the synapse. Effects resulting from selegiline administration may also be mediated through its metabolites. Two of its three principal metabolites, amphetamine and methamphetamine, have pharmacological actions of their own; they interfere with neuronal uptake and enhance release of several neurotransmitters e.
US Pharmacopeial Convention, Inc; Pharmacokinetics and safety of a selegiline transdermal system relative to single-dose oral administration in the elderly, selegiline 2 mg.
Clinical pharmacokinetics and pharmacodynamics of selegiline. Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration. Transdermal selegiline in HIV-associated cognitive impairment: Selegiline transdermal system Somerset. Curr Opin Investig Drugs, selegiline 2 mg. Selegiline selegiline in major depression:
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