Tizanidine 10 mg - Tizanidine Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, tizanidine 10 mg, and it may be useful to monitor renal function. Clinical studies of Tizanidine Tablets, USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently than younger subjects, tizanidine 10 mg. Cross-study comparison of pharmacokinetic tizanidine following single dose administration of 6 mg Tizanidine Tizanidine, USP showed that younger subjects cleared the drug four times faster than the elderly subjects.
During titration, the individual doses should be reduced. If higher doses are required, individual doses rather than dosing frequency should be increased.
Monitor elderly patients because they may have an increased risk for adverse reactions associated with Tizanidine Tablets, USP.
I was given a doctor prescription of Tizanidine 4mg for muscle spasticity. Did it affect my spasms?
Impaired Renal Function Tizanidine Tablets, USP is known to be substantially tizanidine by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function.
In these patients, during titration, the individual doses should be reduced, tizanidine 10 mg. These patients should be monitored closely for the onset or increase in severity of the common adverse events dry mouth, somnolence, tizanidine 10 mg, asthenia and dizziness as indicators of potential overdose.
Because Tizanidine is extensively metabolized in the liver, hepatic impairment would be expected to have significant effects on pharmacokinetics tizanidine Tizanidine.
Drug Abuse and Dependence Abuse Abuse potential was not evaluated in human studies. Rats were able to distinguish Tizanidine from saline in a standard discrimination paradigm, after training, but failed to generalize tizanidine effects of morphine, cocaine, diazepam, or phenobarbital to Tizanidine.
Dependence Tizanidine is closely related to clonidine, which is often abused in combination with narcotics and is known to cause symptoms of rebound upon abrupt withdrawal. Three cases of rebound symptoms on sudden withdrawal of Tizanidine have been reported. The case reports suggest that these patients were also misusing narcotics, tizanidine 10 mg.
Withdrawal symptoms included hypertension, tachycardia, hypertonia, tremor, and anxiety. Withdrawal symptoms are more likely to occur in cases where high doses are used, especially for prolonged periods, or with concomitant use of narcotics.
Tizanidine HCL
If therapy needs to be discontinued, the dose should be decreased slowly to minimize the risk of withdrawal symptoms [ see Dosage and Administration 2. These transient withdrawal signs increased locomotion, body twitching, tizanidine 10 mg, and aversive behavior toward the observer were not reversed by naloxone administration. Overdosage A review of the safety surveillance database revealed cases of intentional and accidental Tizanidine Tablets, USP overdose.
Some of the cases tizanidine in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants, tizanidine 10 mg. The clinical manifestations of Tizanidine overdose were consistent with its known pharmacology, tizanidine 10 mg. In the majority of cases a decrease in sensorium was observed including lethargy, somnolence, confusion and coma.
Depressed cardiac function is also observed including most often bradycardia and hypotension. Respiratory depression is another common tizanidine of Tizanidine overdose.
In some situations, it may endanger your physical safety to be in a state of reduced muscle tone. Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.
Do not take more than three doses 36 mg of tizanidine in a hour period. Too much of this medicine can damage your liver.
Cold or allergy medicine, tizanidine pain medicine, sleeping pills, tizanidine 10 mg, other muscle relaxers, and tizanidine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. It can increase some of the side effects of this medicine. Before taking this medicine You should not use tizanidine if you are allergic tizanidine it, or if: To make sure this medicine is safe for you, tell your doctor if you have: It is not known whether this medicine will harm an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby, tizanidine 10 mg.
Tell your doctor if you are breast-feeding a baby. Clinical studies of Zanaflex did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently than younger subjects, tizanidine 10 mg. Crossstudy comparison of pharmacokinetic data following single dose administration of 6 mg Zanaflex showed that younger subjects cleared the drug four times tizanidine than the elderly subjects.
During titration, the individual doses should be reduced. Monitor elderly patients because they may have an increased risk for adverse reactions associated with Zanaflex.
Impaired Renal Function Zanaflex is known to be substantially excreted by the kidney, tizanidine 10 mg, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function.
These patients should be monitored closely for the onset or increase in severity of the common adverse events dry mouthsomnolence, asthenia and dizziness as indicators of potential overdose. Because tizanidine is extensively metabolized in the liver, hepatic impairment would be expected to have significant effects on pharmacokinetics of tizanidine. Some of the cases resulted in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants.
The clinical manifestations of tizanidine overdose were consistent with its known pharmacology. In the majority of cases tizanidine decrease in sensorium was observed including lethargysomnolencetizanidine 10 mg, confusion and coma, tizanidine 10 mg. Depressed cardiac function is also observed including most often bradycardia and hypotension.
Respiratory depression is another common feature of tizanidine overdose. Should overdose occur, tizanidine 10 mg, basic steps to ensure the adequacy of an airway and the monitoring of cardiovascular and respiratory systems should be undertaken. Tizanidine is a lipid -soluble drug, which is only slightly soluble tizanidine water and methanol. Therefore, dialysis is not likely to be an efficient method tizanidine removing drug from the body.
Tizanidine
In general, symptoms resolve within one to three days following discontinuation of tizanidine and administration of appropriate therapy, tizanidine 10 mg. Due to the similar mechanism of action, symptoms and management of tizanidine overdose are similar to that following clonidine overdose. For the most recent information concerning the management of overdose, contact a poison control center. The effects of tizanidine are greatest on polysynaptic pathways.
The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. Pharmacokinetics Absorption and Distribution Following oral administration, tizanidine 10 mg, tizanidine is essentially completely absorbed. Tizanidine is tizanidine distributed throughout the body with a mean steady state volume of distribution of 2. A single dose of either two 4 mg tablets or two 4 mg capsules was administered under fed and fasting conditions in an open label, four period, randomized crossover study in 96 human volunteers, tizanidine whom 81 were eligible for the statistical analysis.
Following oral administration of either the tablet or capsule in the fasted statepeak plasma concentrations of tizanidine occurred 1, tizanidine 10 mg. Food also increased the extent of absorption for both the tablets and tizanidine.
tizanidine (Zanaflex)
Administration of the capsule contents sprinkled on applesauce was not bioequivalent to administration of an intact capsule under fasting conditions. Mean Tizanidine Concentration vs.
Tizanidine has a half-life of approximately 2. Tizanidine metabolites are not known to be active; their half-lives range from 20 to 40 hours. Special Populations Age Effects No specific pharmacokinetic tizanidine was conducted to investigate age effects.
Cross study comparison of pharmacokinetic data following single dose administration of 6 mg Zanaflex showed that younger subjects cleared the drug four times faster than the elderly subjects. How should I take tizanidine Zanaflex?
Take this medication exactly as it was prescribed for you, tizanidine 10 mg.
Do not take the medication in larger amounts, or take it for longer than recommended by your doctor, tizanidine 10 mg. Follow the directions on your tizanidine label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take this medication with a full glass of water. Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 6 hours after you tizanidine it.
This medication should be taken only for daily activities that require relief from muscle spasticity. In most cases, tizanidine 10 mg, you may take up to three doses in one day if needed. Allow 6 to 8 hours to pass between doses.
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