Information from the manufacturer GlaxoSmithKline includes pregnancy outcomes involving first trimester exposure to this medication. Read More The CDC recommends intravaginal clindamycin cream should only be used during the first half of pregnancy.
Antibiotics given to pregnant women are studied carefully and have the least potential effects to the growth and development of the baby. Bacterial Vaginosis can cause preterm labor and problems with fertility if it is not treated properly. They like to clear it up quickly in pregnancy as there is apparently a link with premature labour I'm not sure in the first trimester as it was quite late in my pregnancy but they treated mine with metronidazole oral tablets Read More Systemic medications are best avoided during pregnancy while topical medications also need to be used sparingly.
Interactions that can increase side effects When clindamycin is used with certain drugs, it may result in more side effects. This is because the amount of clindamycin in your body may be increased. Drugs called CYP3A4 inhibitors, such as ketoconazole. These drugs may increase how much clindamycin your body absorbs. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings. Allergy warning Clindamycin can cause a severe allergic reaction. Taking it again could be fatal cause death. Warnings for people with certain health conditions For people with gastrointestinal disease: If you have a gastrointestinal issue, such as inflammation of your colon, ask your doctor whether this drug is safe for you.
This drug can cause severe diarrhea and inflammation of your colon. This can make your condition worse. For people with allergies: Therefore inhibitors of CYP3A4 and CYP3A5 may increase plasma concentrations of clindamycin and inducers of these isoenzymes may reduce plasma concentrations of clindamycin. In the presence of strong CYP3A4 inhibitors, monitor for adverse reactions.
In the presence of strong CYP3A4 inducers such as rifampicin, monitor for loss of effectiveness. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals have not been performed with clindamycin to evaluate carcinogenic potential. Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test. Both tests were negative. Pregnancy Teratogenic effects In clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters, has not been associated with an increased frequency of congenital abnormalities.
Clindamycin should be used during the first trimester of pregnancy only if clearly needed. There are no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy.
Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if clearly needed. Nursing Mothers Clindamycin has been reported to appear in breast milk in the range of 0. Clindamycin has the potential to cause adverse effects on the breastfed infant's gastrointestinal flora.
If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Monitor the infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash or rarely, blood in the stool indicating possible antibiotic-associated colitis.
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects on the breastfed child from clindamycin or from the underlying maternal condition. Geriatric Use Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. These patients should be carefully monitored for the development of diarrhea.
Pharmacokinetic studies with clindamycin have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal age-adjusted renal function after oral or intravenous administration. Clostridium difficile colitis Gastrointestinal: Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration. Generalized mild to moderate morbilliform-like maculopapular skin rashes are the most frequently reported adverse reactions.
Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy.
Tags: alcohol and motrin 600mg keppra 25mg buy transdermal verapamil
© Copyright 2017 Clindamycin hcl 300mg safe during pregnancy. Clindamycin, Oral Capsule.