Talk to your doctor if you are using marijuana. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs.
When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Older adults may be more sensitive to the side effects of Risperdal Consta Injection Risperidone Drowsiness, dizziness, and lightheadedness can increase the risk of falling. Babies born to mothers who have used Risperdal Consta Injection Risperidone If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.
If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using Risperdal Consta Injection Risperidone Consult your doctor before breast-feeding even if you have stopped Risperdal Consta Injection Risperidone It works by helping to restore the balance of certain natural substances in the brain.
It is given as directed by your doctor, usually once every two weeks. To reduce irritation from the injection, your doctor will alternate between the left and right side with each dose. When you first start Risperdal Consta Injection Risperidone During this time, your doctor will instruct you to take another medication by mouth.
Follow your doctor's instructions carefully. Elderly women patients appeared to be at increased risk for TD, although it is impossible to predict which patients will develop the syndrome. Prescribing should be consistent with the need to minimize the risk of TD see full Prescribing Information. Discontinue drug if clinically appropriate. The syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. These metabolic changes include hyperglycemia, dyslipidemia, and body weight gain.
While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile. Hyperglycemia and Diabetes Mellitus: Patients starting treatment with APS who have or are at risk for diabetes mellitus should undergo fasting blood glucose testing at the beginning of and during treatment.
Patients who develop symptoms of hyperglycemia should also undergo fasting blood glucose testing. All patients treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia. Monitor glucose regularly in patients with diabetes or at risk for diabetes. Some patients require continuation of anti-diabetic treatment despite discontinuation of the suspect drug.
Undesirable alterations have been observed in patients treated with atypical antipsychotics. The long-term effects of risperidone on growth and sexual maturation have not been fully evaluated in children and adolescents. Therefore, dosing recommendations for otherwise healthy elderly patients are the same as for nonelderly patients. Because elderly patients exhibit a greater tendency to orthostatic hypotension than nonelderly patients, elderly patients should be instructed in nonpharmacologic interventions that help to reduce the occurrence of orthostatic hypotension e.
Concomitant use with Furosemide in Elderly Patients with Dementia-Related Psychosis In two of four placebo-controlled trials in elderly patients with dementia-related psychosis, a higher incidence of mortality was observed in patients treated with furosemide plus oral risperidone when compared to patients treated with oral risperidone alone or with oral placebo plus furosemide. No pathological mechanism has been identified to explain this finding, and no consistent pattern for cause of death was observed.
An increase of mortality in elderly patients with dementia-related psychosis was seen with the use of oral risperidone regardless of concomitant use with furosemide. In general, reported signs and symptoms were those resulting from an exaggeration of the drug's known pharmacological effects, i. One case, involving an estimated overdose of mg, was associated with hyponatremia , hypokalemia , prolonged QT, and widened QRS. Another case, involving an estimated overdose of 36 mg, was associated with a seizure.
In general, the most frequently reported signs and symptoms are those resulting from an exaggeration of the drug's known pharmacological effects, i. Management Of Overdosage In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias.
If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry a theoretical hazard of QT prolonging effects that might be additive to those of risperidone. Similarly, it is reasonable to expect that the alpha-blocking properties of bretylium might be additive to those of risperidone, resulting in problematic hypotension. There is no specific antidote to risperidone.
Therefore, appropriate supportive measures should be instituted. The possibility of multiple drug involvement should be considered. In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision and monitoring should continue until the patient recovers. However, it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine Type 2 D2 and serotonin Type 2 5HT2 receptor antagonism.
The main release of the drug starts from 3 weeks onward, is maintained from 4 to 6 weeks, and subsides by 7 weeks following the intramuscular IM injection. Steady-state plasma concentrations are reached after 4 injections and are maintained for 4 to 6 weeks after the last injection. Deltoid and gluteal intramuscular injections at the same doses are bioequivalent and, therefore, interchangeable.
Distribution Once absorbed, risperidone is rapidly distributed. Neither risperidone nor 9-hydroxyrisperidone displaces each other from plasma binding sites. Metabolism and Drug Interactions Risperidone is extensively metabolized in the liver. The main metabolic pathway is through hydroxylation of risperidone to 9-hydroxyrisperidone by the enzyme, CYP 2D6.
A minor metabolic pathway is through N-dealkylation. The main metabolite, 9-hydroxyrisperidone, has similar pharmacological activity as risperidone. Consequently, the clinical effect of the drug results from the combined concentrations of risperidone plus 9-hydroxyrisperidone.
This condition can develop after a brief period of therapy at low doses, although this is much less common. There is no known treatment for TD, but it may go away partially or completely if therapy is stopped. These changes may include: If you already have diabetes or have risk factors such as being overweight or a family history of diabetes, blood sugar testing should be done at the beginning and during the treatment.
The complications of diabetes can be serious and even life-threatening. Call your doctor if you develop signs of high blood sugar or diabetes, such as being thirsty all the time, having to urinate or "pass urine" more often than usual, or feeling weak or hungry. Changes in cholesterol and triglycerides have been noted in patients taking atypical antipsychotics.
The clearance of risperidone and risperidone plus 9hydroxyrisperidone was Alcohol or marijuana can make you more dizzy or drowsy. These doses are equivalent to 2. SSRIs and consta antidepressants: This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients, risperdal consta price. Some patients require continuation of anti-diabetic treatment despite discontinuation of the suspect drug, risperdal consta price. Manifestation of this increased sensitivity can include confusion, obtundation, postural instability with frequent falls, in addition to extrapyramidal symptoms. If you price other effects not risperdal above, contact your doctor or pharmacist. Risperdal half-life of days is related to the erosion of the microspheres and subsequent absorption of risperidone. When using concomitant medication, the corresponding label should be consulted for information on the price of metabolism and the possible need to consta dosage. Elderly Patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death compared to placebo.
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