I am now lbs. Being so heavy makes me very depressed and antisocial. I am no longer who I was before starting this. I was happier being crazy. Proctor February 22, , 9: Another horrible side-effect is having hot flashes and excessive sweating. After numerous episodes of sweating through my clothes, I had to buy a fan for my desk at work.
Reply Link Renee C December 23, , 8: I take it in addition to 3 mg. Lunesta worked great all by itself for a couple years until I built up a tolerance to it.
After I went off it and started taking Lunesta I was able to lose 50 lbs. Need someone to play Santa Claus at your house this year? Have you ever taken Zopiclone? It was the only medication that would put me to sleep whet fractured my spine. The other bonus is it is not habit forming. No weight gain with it.
Reply Link Christina K March 8, , 4: This is the last thing I needed for my depression, to gain weight. Reply Link Sue February 2, , 4: The first two months I put on 6 lbs, so decided after Christmas I would have to do something about my weight before it got worse.
I started a low carb healthy fat diet on the 1st of Jan and have thus far lost 12 lbs. I have always been aware of my diet after loosing 50kg some years back. Good luck to all who are trying to lose weight — it is possible.
Reply Link Paul Grant January 26, , 2: In the past 6 months I have rapidly gained over 30 lbs. I went from lbs to lbs. At first it was slow and then it became rapid. I am a hard gainer and have hovered in between for years. Seroquel is supplied for oral administration as 25 mg round, peach , 50 mg round, white , mg round, yellow , mg round, white , mg capsule-shaped, white , and mg capsule-shaped, yellow tablets.
Inactive ingredients are povidone, dibasic dicalcium phosphate dihydrate, microcrystalline cellulose, sodium starch glycolate, lactose monohydrate, magnesium stearate, hypromellose, polyethylene glycol and titanium dioxide. The 25 mg tablets contain red ferric oxide and yellow ferric oxide and the mg and mg tablets contain only yellow ferric oxide. However, it has been proposed that the efficacy of Seroquel in schizophrenia and its mood stabilizing properties in bipolar depression and mania are mediated through a combination of dopamine type 2 D2 and serotonin type 2 5HT2 antagonism.
Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other effects of Seroquel.
Pharmacodynamics Seroquel is an antagonist at multiple neurotransmitter receptors in the brain: However, the QT effect was not systematically evaluated in a thorough QT study. In post marketing experience there were cases reported of QT prolongation in patients who overdosed on quetiapine [see Overdosage Pharmacokinetics Adults Quetiapine fumarate activity is primarily due to the parent drug.
The multiple-dose pharmacokinetics of quetiapine are dose-proportional within the proposed clinical dose range, and quetiapine accumulation is predictable upon multiple dosing. Elimination of quetiapine is mainly via hepatic metabolism with a mean terminal half-life of about 6 hours within the proposed clinical dose range. Steady-state concentrations are expected to be achieved within two days of dosing.
Quetiapine is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P enzymes. Children and Adolescents At steady-state, the pharmacokinetics of the parent compound, in children and adolescents years of age , were similar to adults. When adjusted for dose and weight, the pharmacokinetics of the metabolite, norquetiapine, was similar between children and adolescents and adults [see Use in Specific Populations 8.
Absorption Quetiapine fumarate is rapidly absorbed after oral administration, reaching peak plasma concentrations in 1. In vitro, quetiapine did not affect the binding of warfarin or diazepam to human serum albumin. In turn, neither warfarin nor diazepam altered the binding of quetiapine. Quetiapine is extensively metabolized by the liver. The major metabolic pathways are sulfoxidation to the sulfoxide metabolite and oxidation to the parent acid metabolite; both metabolites are pharmacologically inactive.
In vitro studies using human liver microsomes revealed that the cytochrome P 3A4 isoenzyme is involved in the metabolism of quetiapine to its major, but inactive, sulfoxide metabolite and in the metabolism of its active metabolite N-desalkyl quetiapine.
Gender There is no gender effect on the pharmacokinetics of quetiapine. Race There is no race effect on the pharmacokinetics of quetiapine. Or were you at home alone, maybe at the end of a tough day? How did you feel afterward -- simply annoyed that you gave yourself a stomachache?
Or were you tormented by guilt or shame? Eating too much every once in a while is normal. So is eating for emotional reasons. Patients were randomly assigned to take one of three doses of Seroquel or a placebo once a day for six weeks. Those taking Seroquel showed greater improvement in depression symptoms than those on placebo. Importantly, patients on Seroquel experienced a significant improvement in depressive symptoms as early as the fourth day of treatment, Weisler says.
And often it can take up to a month," he says. These symptoms should be reported immediately to the doctor. These may be symptoms of a rare, but very serious and potentially fatal, side effect called neuroleptic malignant syndrome NMS.
If you have diabetes or risk factors such as obesity or a family history of diabetes, your doctor should check your blood sugar before you start taking SEROQUEL XR and also during therapy. If you develop symptoms of high blood sugar or diabetes, such as excessive thirst or hunger, increased urination, or weakness, contact your doctor. Complications from diabetes can be serious and even life threatening.
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