For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse. For people with liver problems: If you have liver problems or a history of liver disease, your body may not be able to process this drug as well.
Warnings for other groups For pregnant women: This drug is a category C pregnancy drug. That means two things: Research in animals has shown adverse effects to the fetus when the mother takes the drug.
This drug should only be used if the potential benefit justifies the potential risk to the fetus. Call your doctor right away if you become pregnant while taking this drug. For women who are breastfeeding: This drug may pass into breast milk and may cause side effects in a child who is breastfed.
Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. If you are over the age of 65 years, you may be at higher risk of developing muscle problems while taking this drug, including low salt levels in the blood known as hyponatremia.
This medication has not been studied in children as treatment for major depressive disorder, panic disorder, posttraumatic disorder, social anxiety disorder, and premenstrual dysphoric disorder.
It should not be used for these disorders in people younger than 18 years. This medication has only been studied in children with obsessive-compulsive disorder. For treatment of obsessive-compulsive disorder, it should not be used in people younger than 6 years. Your doctor may occasionally change your dose to make sure you get the best results. Sertraline may be taken with or without food. Try to take the medicine at the same time each day.
The liquid form of sertraline must be diluted before you take it. To be sure you get the correct dose, measure the liquid with the medicine dropper provided. Do not use any other liquids to dilute the medicine. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away. This medication can cause you to have a false positive drug screening test.
If you provide a urine sample for drug screening, tell the laboratory staff that you are taking sertraline. It may take up to 4 weeks before your symptoms improve. Do not stop using sertraline without first talking to your doctor.
Sertraline does not have significant affinity for the norepinephrine transporter NET or the serotonin , dopamine , adrenergic , histamine , or acetylcholine receptors. In the blood, it is According to in vitro studies, sertraline is metabolized by multiple cytochrome isoforms: It appeared unlikely that inhibition of any single isoform could cause clinically significant changes in sertraline pharmacokinetics.
These conclusions have not been verified in human studies. Sertraline deaminated is O , a compound that has been found to inhibit the dopamine reuptake transporter proteins in spite of its lack of a nitrogen atom.
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