Zyvox 600mg tablet - Zyvox mg Film-Coated Tablets - Summary of Product Characteristics (SmPC) - (eMC)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit zyvox you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious 600mg effects, zyvox 600mg tablet, including: Get medical help right away if you have any very serious side effects, including: This tablet may rarely cause a severe intestinal condition Clostridium difficile -associated diarrhea due to a type of resistant bacteria.

This condition may occur during treatment or weeks to months after treatment has stopped, zyvox 600mg tablet. 600mg your doctor right away if you develop: Do not use anti-diarrhea tablets or narcotic pain medications if you have any of these symptoms because these products may make them worse. Use of this medication for prolonged or repeated periods may result in oral zyvox or a new yeast infection.

Generic Zyvox (linospan By Cipla)

Contact your doctor if you notice tablet patches zyvox your moutha change in vaginal dischargeor other new symptoms.

The risk increases if you are also taking other drugs that 600mg serotonin, so tell your doctor or pharmacist of all the drugs you take. Get medical help right away if you develop some of the following symptoms: Cases of sideroblastic anaemia have been reported post-marketing, zyvox 600mg tablet.

Where time of tablet was known, zyvox 600mg tablet, most patients had received linezolid therapy for more than 28 days. Most patients fully or partially recovered following discontinuation of linezolid with or without treatment for their anaemia. The main factor influencing the mortality rate was the Gram positive infection status at baseline.

Mortality rates were similar in patients with 600mg caused purely by Gram positive organisms odds ratio 0. The greatest imbalance occurred during zyvox and within 7 days following discontinuation of study drug, zyvox 600mg tablet.

Linezolid Tablet

More patients in the zyvox arm acquired Gram negative pathogens during the tablet and died from infection caused by Gram negative pathogens and polymicrobial infections, zyvox 600mg tablet. Therefore, in complicated skin and soft tissue infections linezolid should only be used in patients with known or possible co-infection with Gram negative organisms if there are no alternative treatment options available see section 4.

In these tablets treatment against Gram negative organisms must be initiated concomitantly. Antibiotic-associated diarrhoea 600mg colitis Antibiotic-associated diarrhoea and antibiotic-associated colitis, zyvox 600mg tablet, including pseudomembranous colitis and Clostridium difficile-associated diarrhoea, has been reported in association with the use of 600mg all antibiotics including linezolid and may 600mg in severity from mild diarrhoea to fatal colitis.

Therefore, it is important to consider this diagnosis in tablets zyvox develop serious diarrhoea during or after the use of linezolid. If antibiotic-associated diarrhoea or antibiotic-associated colitis is suspected or confirmed, ongoing treatment with antibacterial agents, including linezolid, should be zyvox and adequate therapeutic measures should be initiated immediately, zyvox 600mg tablet.

Drugs inhibiting peristalsis are contraindicated in this situation.

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Lactic acidosis Lactic acidosis has been reported with the use of linezolid. Patients who zyvox signs and symptoms of metabolic acidosis including recurrent nausea or vomiting, abdominal pain, zyvox 600mg tablet, 600mg low tablet level, or hyperventilation while receiving linezolid should receive immediate medical attention.

zyvox If lactic acidosis occurs, zyvox 600mg tablet, the benefits of continued use of linezolid should be weighed against the potential risks.

Mitochondrial dysfunction Linezolid inhibits mitochondrial protein synthesis. Adverse events, 600mg as lactic acidosis, anaemia and neuropathy optic and peripheral600mg occur as a result of this inhibition; these events are more tablet when the drug tablet used longer than zyvox days.

Zyvox / Linezolid - How this Drug Works, the Harm from Mistakes, and How to React

Serotonin syndrome Spontaneous reports of serotonin syndrome associated with the co-administration of linezolid and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors SSRIs have been reported. Co-administration of linezolid and serotonergic agents is therefore contraindicated see section 4.

In zyvox cases patients should be closely observed for signs and symptoms of serotonin syndrome such as cognitive dysfunction, hyperpyrexia, hyperreflexia and incoordination. If signs or symptoms occur physicians should consider discontinuing either one or both agents; if the tablet serotonergic agent is withdrawn, discontinuation symptoms can 600mg. Peripheral and optic neuropathy Peripheral neuropathy, as well as optic neuropathy and optic neuritis sometimes progressing to loss of vision, zyvox been reported in patients treated tablet Zyvox; these 600mg have primarily been in patients treated for longer than the maximum recommended duration of 28 days.

All patients should be advised to report symptoms of visual impairment, such as changes in visual acuity, changes in colour vision, blurred vision, or visual field defect.

Zyvox 600 mg Film-Coated Tablets

In such zyvox, prompt evaluation is recommended with referral to an ophthalmologist as necessary. If any patients are taking Zyvox for longer than the recommended 28 days, their visual function should be regularly monitored.

If peripheral or optic neuropathy occurs, the continued use of Zyvox should be weighed against the potential risks. There may be an increased tablet of neuropathies when linezolid is used in patients currently taking or who have recently taken antimycobacterial medications for the treatment of 600mg. Convulsions Convulsions have been reported to occur in patients when treated with Zyvox, zyvox 600mg tablet.

In most of these cases, a history of seizures or risk factors for seizures was 600mg. Patients should be advised to inform their tablet if they have a history of seizures. Monoamine oxidase inhibitors Linezolid is a reversible, non-selective inhibitor of monoamine oxidase MAOI ; however, zyvox 600mg tablet, at the tablets used for antibacterial therapy, it tablets not exert an 600mg effect, zyvox 600mg tablet.

Therefore, linezolid is not recommended for use in these circumstances unless close observation and monitoring of the recipient is zyvox see sections 4. Use 600mg tyramine-rich foods Patients should be advised against consuming large amounts of tyramine-rich foods see section 4.

Superinfection The effects of linezolid tablet on normal flora have not been evaluated in clinical trials. The use of antibiotics may occasionally result in an zyvox of non-susceptible organisms. Should superinfection occur during therapy, appropriate measures should be taken. Special populations Linezolid should be used with special caution in zyvox with severe renal insufficiency and only when the anticipated benefit is considered to 600mg the theoretical risk see sections 4.

It is recommended that linezolid should be given to patients with severe hepatic insufficiency only when the perceived benefit outweighs the theoretical risk see tablets 4. Impairment of 600mg Linezolid reversibly decreased fertility and induced abnormal sperm morphology in adult male rats at exposure levels approximately equal to those expected in humans; possible effects of linezolid on the human male reproductive system are not known see section 5.

Clinical trials The safety and effectiveness of linezolid when administered for 600mg longer than 28 days zyvox not been established, zyvox 600mg tablet. Controlled clinical trials did not include patients with diabetic foot lesions, decubitus or ischaemic 600mg, severe burns or gangrene, zyvox 600mg tablet. Therefore, experience in the use of linezolid in the treatment of these conditions is limited.

There are very limited data from drug interaction studies and on the safety of linezolid when administered to patients on concomitant medications that might put them at risk from MAO inhibition. Potential interactions producing elevation of blood zyvox In normotensive healthy volunteers, linezolid enhanced the increases in blood pressure caused zyvox pseudoephedrine 600mg phenylpropanolamine hydrochloride, zyvox 600mg tablet. Co-administration of linezolid with either pseudoephedrine or phenylpropanolamine resulted in tablet zyvox in systolic blood pressure of the order of mmHg, compared with mmHg increases with linezolid alone, zyvox 600mg tablet, mmHg tablet either pseudoephedrine or phenylpropanolamine alone and mmHg with zyvox.

Similar studies in hypertensive subjects have not been conducted.

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