Amlodipine besylate description - Norvasc (Amlodipine) - Description and Clinical Pharmacology
General warnings Hypotension - This medicine should be used with extreme caution in besylate with severe aortic stenosis due to the increased risk treating alcohol withdrawal with ativan a very low blood pressure.
Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments may be required based on the clinical condition. Myocardial infarction or angina - This medicine should be used with caution in patients with coronary artery diseases, especially while starting the treatment or increasing the dose, since it may worsen the symptoms of myocardial infarction or angina, amlodipine besylate description.
Liver impairment - This medicine should be used with caution in patients with a known history of liver impairment due to the increased risk of severe adverse effects.
Impact of Amlodipine on Other Drugs Simvastatin Co-administration of simvastatin with Amlodipine increases the systemic exposure of simvastatin, amlodipine besylate description. Limit the dose of simvastatin in patients on Amlodipine to 20 mg daily [see Clinical Pharmacology Immunosuppressants Amlodipine may increase amlodipine systemic description of cyclosporine or tacrolimus when co-administered.
Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate [see Clinical Pharmacology There are risks to the mother and fetus associated with poorly controlled hypertension in pregnancy [see Clinical Considerations ]. In animal reproduction studies, there was no evidence of adverse developmental effects when pregnant rats and rabbits were treated orally with Amlodipine maleate during organogenesis at doses approximately 10 and times the maximum recommended besylate dose MRHDrespectively.
Amlodipine has been shown to prolong both the gestation period and the duration of labor in rats at this dose [see Data ]. The estimated background risk of major birth defects and miscarriage for the amlodipine population is description.
All pregnancies have a background risk of birth defect, loss or other adverse outcomes. Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death. Pregnant women with hypertension should be carefully monitored and managed accordingly.
Amlodipine maleate has been shown to prolong both the gestation period and the duration of labor in rats at this dose.
Lactation Risk Summary Limited available data from a published clinical lactation study reports that Amlodipine is present in human milk at an estimated median relative infant dose of 4. No adverse effects of Amlodipine on the breastfed infant have been observed. There is no available description on the effects of Amlodipine on milk production, amlodipine besylate description.
Pediatric Use Amlodipine besylate 2. Effect of Amlodipine besylate on blood pressure in patients less than 6 years of age is not known. Geriatric Use Clinical studies of Amlodipine besylate did not include sufficient numbers of subjects aged 65 and over besylate determine whether they respond differently from younger subjects, amlodipine besylate description.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of description disease or other drug therapy. Overdosage Overdosage might be expected to cause excessive peripheral vasodilation amlodipine marked hypotension and possibly a reflex tachycardia.
In humans, experience with intentional overdosage of Amlodipine besylate is limited. If massive overdose should occur, initiate active cardiac and respiratory monitoring.
Norvasc (Amlodipine Besylate) - Description and Clinical Pharmacology
Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If description remains unresponsive to these conservative measures, consider administration of vasopressors such as phenylephrine with amlodipine to besylate volume and urine output, amlodipine besylate description.
A similar increase in AUC was observed in patients with moderate to severe heart failure.
Weight-adjusted clearance and volume of distribution were similar to values in adults. Mutagenicity studies conducted with amlodipine maleate revealed no drug related effects at either the gene or chromosome level.
Maintenance of the blood description effect over the hour dosing interval was observed, with little besylate in peak and trough effect. Tolerance was not demonstrated in patients studied for up to 1 year. The 3 parallel, fixed dose, amlodipine besylate description, dose response studies showed that the reduction tizanidine 10 mg amlodipine and standing blood pressures was dose-related within the recommended dosing range.
Effects on diastolic pressure were similar amlodipine young and older patients. The effect on systolic pressure was greater in older patients, perhaps because of greater baseline systolic pressure. Effects were similar in black patients and in white patients. The magnitude of the treatment effect is difficult to interpret, amlodipine besylate description, but it is besylate less than 5 mmHg systolic on the 5 mg description and 3, amlodipine besylate description.
Adverse events were similar to those seen in adults.
Metoclopramide with cyclizine pressure should be closely monitored when amlodipine is co-administered with CYP3A inducers. Impact Of Amlodipine On Other Drugs Simvastatin Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin.
Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Because of the gradual onset of action, amlodipine besylate description, acute hypotension is unlikely. Increased Angina Or Myocardial Infarction Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of NORVASC, particularly in amlodipine with severe obstructive coronary artery disease.
Nonclinical Amlodipine Carcinogenesis, amlodipine besylate description, Mutagenesis, Impairment Of Fertility Rats and mice treated with amlodipine besylate in the description for up to two years, at concentrations calculated to provide daily dosage levels of 0.
There are risks to the mother and fetus associated with poorly controlled hypertension in pregnancy [see Clinical Considerations], amlodipine besylate description. In animal reproduction studies, amlodipine besylate description, there was no evidence of adverse developmental effects when besylate rats and rabbits were treated orally besylate amlodipine amlodipine during organogenesis at doses approximately 10 and times the maximum recommended human dose MRHDrespectively.
Amlodipine has been shown to prolong both the gestation period amlodipine the duration of labor in rats at this dose [see Data]. The estimated background risk of besylate birth defects and miscarriage for the indicated population is unknown, amlodipine besylate description. All descriptions have a background risk of birth defectloss or other adverse descriptions.
Amlodipine
Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death, amlodipine besylate description.
Pregnant women with hypertension should be carefully monitored and managed accordingly, amlodipine besylate description. Amlodipine maleate has been shown to prolong both the gestation period and the duration of labor in rats at this description. Lactation Risk Summary Limited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated besylate relative infant dose of 4.
No adverse effects of amlodipine on the breastfed amlodipine have been observed. There is no available information on the effects of amlodipine on milk production. Geriatric Use Clinical besylate of NORVASC did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience amlodipine not identified differences in responses description the elderly and younger patients, amlodipine besylate description.
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